Mother Teresa Post Graduate and Research Institute of Health Sciences (MTIHS) was established by the Government of Puducherry. It was setup with the mission to develop the requirements of health care personnel by providing health care educational courses for the Union Territory of Puducherry.

The Institution was started in September, 1991 as ‘Pondicherry Centre for Paramedical Education’ at the Government General Hospital, Puducherry with the four Diploma courses of Medical Laboratory Technology (DMLT), Certified Radiological Assistants (DCRA), Multipurpose Health Worker-Male (DMPHW-M) and Multipurpose Health Worker-Female (DMPHW-F). In the subsequent academic year the two degree courses of Bachelor of Nursing (B.Sc. Nursing) and Bachelor of Physiotherapy (BPT) were started along with two diploma courses of Pharmacy (D.Pharm) and Paramedical Ophthalmic Assistant (DPOA). The diploma courses of D.Pharm. and D.M.L.T were upgraded as degree courses from the academic year 2001-02.